Yes, instruments can be configured to transmit real-time using full-duplex RS-485.  On RBRvirtuoso, RBRduo and RBRconcerto instruments, the logger needs to have the appropriate external battery endcap (either USB, RS-232 or RS-485) for the required external communication mode, as the wiring differs between the options.  Ruskin is then used to configure the instrument with the appropriate streaming data serial option.  For RS-485 communication, you will also need an RS-485 converter at the receive end.